Since the 19th Century, industrial production has massively affected the environment, because its transformations only go in one direction. These unsustainable processes have generated tremendous amounts of waste, which are a great burden on our planet.

The MADONNA Project aims to come up with new chemical reactions to reverse this process in a sustainable way by including new-to–nature reactions into the genome of living beings. MADONNA will use stress conditions and chemo-robots to help microorganisms incorporate into their DNA the ability to perform these chemical transformations. This will allow them to turn industrial waste into a resource, closing the cycle of production.


Biofaction will contribute to MADONNA in the fields of science communication, technology assessment and managing the science-society interface.

MADONNA is a research and innovation project funded by the European Commission. Grant agreement H2020-FETOPEN-1-2016-2017-766975.



Project website:

Project partners:

  • The National Biotechnology Centre of the Spanish National Research Council (CSIC)
  • Université Pierre et Marie Curie (UPMC)
  • ETH Zürich
  • University of Glasgow (UoG)
  • University of Basel
  • Universitat Pompeu Fabra (UPF)
  • Isthmus
  • Biofaction KG