The goal of SinFonia is to design new metabolisms in bacteria to incorporate the element fluorine so that in the future, fluorine containing products can be produced in a biological way instead of with synthetic chemistry.
Miranda developed a method to converge the enzymes, used to handle fluorine in the cell, into musical compositions. This way we can listen how the bacteria incorporates fluorine into its metabolism.
For more details about the process and the residency see:
Miranda E.R. 2023. Making Music with Enzymes
Krink N, Nieto-Domínguez M & Pablo I. 2023. Rewriting the symphony of life with synthetic metabolism – Can enzymes play music?
Schmidt M. 2023. Managing Creative disturbances
Listen to the musical enzymes created by Eduardo Miranda during his residency at Pablo Nikel’s lab.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 814418.